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SCH-23390 hydrochloride

Name: SCH-23390 hydrochloride
Brand: TargetMol
SKU: T4369
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4369Cas No. 125941-87-9

Alias R-(+)-SCH23390 hydrochloride

SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, with high affinity for the D1 (Ki=0.2 nM) and D5 (Ki=0.3 nM) receptors.

SCH-23390 hydrochloride

🥰Excellent

Purity: 99.83%

Catalog No. T4369Alias R-(+)-SCH23390 hydrochlorideCas No. 125941-87-9

SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, with high affinity for the D1 (Ki=0.2 nM) and D5 (Ki=0.3 nM) receptors.

Pack Size	Price	Availability
1 mg	$33	In Stock
2 mg	$46	In Stock
5 mg	$71	In Stock
10 mg	$98	In Stock
25 mg	$205	In Stock
50 mg	$389	In Stock
100 mg	$579	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock

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Purity:99.83%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, with high affinity for the D1 (Ki=0.2 nM) and D5 (Ki=0.3 nM) receptors.
Targets&IC50	5-HT2C receptor:9.3 nM (Ki), GIRK:268 nM, D1:0.2 nM, D5:0.3 nM
In vitro	SCH23390 blocks endogenous GIRK currents induced by either somatostatin or D3 dopamine receptors in AtT-20 cells (IC50=268 nM).SCH 23390 also shows high affinity (Ki=9.3 nM) at h5-HT2C sites.
In vivo	In the rat, the repeated administration of SCH 23390 (0.05 mg/kg s.c., thrice daily for 21 days) enhances the steady-state density of dopamine D1 receptors in the striatum (+30%) and substantia nigra (+24%).
Animal Research	Rats are injected with SCH 23390(0, 1, or 10 μg/kg i.p.).
Synonyms	R-(+)-SCH23390 hydrochloride

Chemical Properties

Molecular Weight	324.24
Formula	C₁₇H₁₉Cl₂NO
Cas No.	125941-87-9
Smiles	Cl.CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 25 mg/mL (77.10 mM), Sonication is recommended.

DMSO: 50 mg/mL (154.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0841 mL	15.4207 mL	30.8414 mL	154.2068 mL
5 mM	0.6168 mL	3.0841 mL	6.1683 mL	30.8414 mL
10 mM	0.3084 mL	1.5421 mL	3.0841 mL	15.4207 mL
20 mM	0.1542 mL	0.7710 mL	1.5421 mL	7.7103 mL
50 mM	0.0617 mL	0.3084 mL	0.6168 mL	3.0841 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0308 mL	0.1542 mL	0.3084 mL	1.5421 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc